Jennifer Aniston has 42 million Instagram followers. In four years, the “Friends” actor, who joined the Facebook-owned app in 2019, amassed 42 million followers. She has 674 Instagram followings and has only posted 124 posts. When she initially joined Instagram in 2019, her first post was a photo of her with her co-stars from their renowned sitcom. Jennifer Aniston recently appeared alongside Adam Sandler in the Netflix film “Murder Mystery 2.”